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Article

DNA methylation of multiple promoter-associated CpG islands in meningiomas: relationship with the allelic status at 1p and 22q.

Acta neuropathologica - 1 Nov 2004

Bello M Josefa, Amiñoso Cinthia, Lopez-Marin Isabel, Arjona Dolores, Gonzalez-Gomez Pilar, Alonso M Eva, Lomas Jesus, de Campos Jose M, Kusak M Elena, Vaquero Jesus, Isla Alberto, Gutierrez Manuel, Sarasa Jose L, Rey Juan A

Abstract excerpt

The purpose of this research was to examine the DNA methylation profile of meningiomas. Accordingly, we examined the DNA methylation status of ten tumor-related genes (RB1, p16(INK4a), p73, MGMT, ER, DAPK, TIMP-3, p14(ARF), THBS1, and Caspase-8) in 98 meningiomas (68 grade I; 27 grade II; and 3 grade III samples) using methylation-specific PCR and sequencing. The most frequently methylated genes were THBS1 (30%),...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15365725
DOI: 10.1007/s00401-004-0911-6

Genes

THBS1
MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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