Article
The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia.
Annals of neurology - 1 Feb 2004
Zarranz Juan J, Alegre Javier, Gómez-Esteban Juan C, Lezcano Elena, Ros Raquel, Ampuero Israel, Vidal Lídice, Hoenicka Janet, Rodriguez Olga, Atarés Begoña, Llorens Verónica, Gomez Tortosa Estrella, del Ser Teodoro, Muñoz David G, de Yebenes Justo G
Abstract excerpt
Familial parkinsonism and dementia with cortical and subcortical Lewy bodies is uncommon, and no genetic defect has been reported in the previously described sibships. We present a Spanish family with autosomal dominant parkinsonism, dementia, and visual hallucinations of variable severity. The postmortem examination showed atrophy of the substantia nigra, lack of Alzheimer pathology, and numerous Lewy bodies...
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