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Article

Flanking gene and genetic background problems in genetically manipulated mice.

Biological psychiatry - 15 Sept 2004

Crusio Wim E

Abstract excerpt

Mice carrying engineered genetic modifications have become an indispensable tool in the study of gene functioning. The interpretation of results obtained with targeted mutants is not completely straightforward, however, because of genetic complications due to linkage and epistasis. Effects of closely linked genes flanking the targeted locus might sometimes be responsible for phenotypic changes ascribed to the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 15364034
DOI: 10.1016/j.biopsych.2003.12.026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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