Influence of genetic background on genetically engineered mouse phenotypes.

Abstract excerpt

The history of mouse genetics, which involves the study of strain-dependent phenotype variability, makes it clear that the genetic background onto which a gene-targeted allele is placed can cause considerable variation in genetically engineered mouse (GEM) phenotype. This variation can present itself as completely different phenotypes, as variations in penetrance of phenotype, or as variable expressivity of...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to GEM gene
• Share to Genetic Engineering
• Share to Genetic Variation