Article
Distribution of a single nucleotide polymorphism on codon 211 of the androgen receptor gene and its correlation with human renal cell cancer in Japanese patients.
Biochemical and biophysical research communications - 20 Aug 2004
Sasaki Masahiro, Nomoto Mitsuharu, Yonezawa Suguru, Nakagawa Masayuki, Sakuragi Noriaki, Fujimoto Seiichiro, Carroll Peter R, Dahiya Rajvir
Abstract excerpt
The human androgen receptor (AR) gene contains a single nucleotide polymorphism (SNP) on codon 211 and two polymorphic short tandem repeats of CAG and GGC in the N-terminal domain that may influence transcription efficiency of AR gene. We previously reported that the lengths of the CAG and GGC repeats are inversely and linearly related to AR activity and associated with several cancers. However, little is known...
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