Article
Single nucleotide polymorphisms of estrogen receptor alpha in human renal cell carcinoma.
Biochemical and biophysical research communications - 6 Sept 2002
Tanaka Yuichiro, Sasaki Masahiro, Kaneuchi Masanori, Fujimoto Seiichiro, Dahiya Rajvir
Abstract excerpt
Estrogens and their receptors (ERs) have been shown to play a role in various cancers. We hypothesize that polymorphisms and genotypic changes of the ERalpha gene are involved in renal cell carcinoma. To test this hypothesis, DNA samples from 113 cases of human renal cell cancer were analyzed by sequence-specific polymerase chain reaction to determine the genotypic frequency of six different polymorphic loci on...
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