Article
The presence of <i>BRAF</i> point mutation in adult papillary thyroid carcinomas from atomic bomb survivors correlates with radiation dose
21 Dec 2006
Abstract excerpt
In papillary thyroid carcinogenesis, the constitutively activated mitogen-activated protein (MAP) kinase signaling pathway caused by a genetic alteration such as RET/PTC rearrangement or mutation of RAS and BRAF genes, is thought to be a major early event. Among these, the recently identified BRAF(V600E) mutation has been found at high frequency in adult patients with papillary thyroid carcinoma (PTC). However,...
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