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Article

Pattern of radiation-induced RET and NTRK1 rearrangements in 191 post-chernobyl papillary thyroid carcinomas: biological, phenotypic, and clinical implications.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Mar 2000

Rabes H M, Demidchik E P, Sidorow J D, Lengfelder E, Beimfohr C, Hoelzel D, Klugbauer S

Abstract excerpt

Molecular genetic aberrations and the related phenotypes were investigated in 191 papillary thyroid carcinomas (PTCs) from patients exposed at young age to radioiodine released from the Chernobyl reactor. A high prevalence of RET gene rearrangements (62.3%) with a significant predominance of ELE1/RET (PTC3) over H4/RET (PTC1) rearrangements was found in PTCs of the first post-Chernobyl decade. NTRK1...

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Topics

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Share to Carcinoma, Papillary
Share to Dose-Response Relationship, Radiation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Rearrangement

Share to Neoplasms, Radiation-Induced

Share to Proto-Oncogene Proteins c-ret

Share to Radioactive Hazard Release

Share to Receptor Protein-Tyrosine Kinases

Share to Receptor, trkA

Source

Identifiers

PMID: 10741739

Genes

RET
NTRK1
GOLGA5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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