Article
Involvement of the nonhomologous region of subunit A of the yeast V-ATPase in coupling and in vivo dissociation.
The Journal of biological chemistry - 19 Nov 2004
Shao Elim, Forgac Michael
Abstract excerpt
The catalytic nucleotide binding subunit (subunit A) of the vacuolar proton-translocating ATPase (or V-ATPase) is homologous to the beta-subunit of the F-ATPase but contains a 90-amino acid insert not present in the beta-subunit, termed the nonhomologous region. We previously demonstrated that mutations in this region lead to changes in coupling of proton transport and ATPase activity and to inhibition of in vivo...
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