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Article

Marked inhibition of retinal neovascularization in rats following soluble‐flt‐1 gene transfer

30 Mar 2004

Abstract excerpt

BACKGROUND: In mouse models of retinopathy of prematurity (ROP) inhibitors of vascular endothelial growth factor (VEGF) functions administered systemically completely block retinal neovascularization. In contrast, selective ocular VEGF depletion has achieved an approx. 50% inhibition of retinal neovascular growth. It is unclear whether a more complete inhibition of new blood vessel development can be obtained...

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PMID: 15352072
DOI: 10.1002/jgm.586

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