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Selective treatment pressure in colon cancer drives the molecular profile of resistant circulating tumor cell clones

8 Feb 2021

Abstract excerpt

The characterization of circulating tumor cells (CTCs) holds promises for precision medicine because these cells are an important clinical indicator of treatment efficacy. We established the first and still only nine permanent colon CTC lines from peripheral blood samples of a patient with metastatic colon cancer collected at different time points during treatment and cancer progression. The study objectives were...

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PMID: 33557844
DOI: 10.1186/s12943-021-01326-6

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