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Article

Endothelins and hypoxia-inducible factor in cancer

1 Jun 2007

Abstract excerpt

The endothelin system is a family of three similar small peptides, two G-protein-coupled receptors and two proteinases. Endothelins have several physiological roles, notably in embryonic differentiation and vascular homeostasis. Numerous types of tumour express endothelins and their regulation is often aberrant when compared with the normal tissue from which the tumour arose. However, endothelin expression is...

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PMID: 17639040
DOI: 10.1677/erc-07-0057

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