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Article

Effects of telomerase modulation in human hematopoietic progenitor cells.

Stem cells (Dayton, Ohio) - 1 Jan 2004

Zimmermann Stefan, Glaser Stefanie, Ketteler Robin, Waller Cornelius F, Klingmüller Ursula, Martens Uwe M

Abstract excerpt

Loss of telomeric repeats has been causally linked to replicative senescence and aging in human cells. In contrast to normal somatic cells, which are telomerase-negative, hematopoietic stem cells have low levels of telomerase, which can be transiently upregulated upon cytokine stimulation. To examine whether ectopic expression of telomerase can overcome telomere erosion in hematopoietic progenitor cells, we...

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Share to Antigens, CD34
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15342938
DOI: 10.1634/stemcells.22-5-741

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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