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Article

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase.

Proceedings of the National Academy of Sciences of the United States of America - 14 Sept 2004

Roux Philippe P, Ballif Bryan A, Anjum Rana, Gygi Steven P, Blenis John

Abstract excerpt

Tuberous sclerosis complex (TSC) is a genetic disorder caused by mutations in either of the two tumor suppressor genes TSC1 or TSC2, which encode hamartin and tuberin, respectively. Tuberin and hamartin form a complex that inhibits signaling by the mammalian target of rapamycin (mTOR), a critical nutrient sensor and regulator of cell growth and proliferation. Phosphatidylinositol 3-kinase (PI3K) inactivates the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ribosomal Protein S6 Kinases, 90-kDa

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Source

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Identifiers

PMID: 15342917
DOI: 10.1073/pnas.0405659101
PMCID: PMC518784

Genes

TSC1
TSC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase.PMID 15342917Read ↗

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