Conditional probability methods for haplotyping in pedigrees.

doi:10.1534/genetics.103.021055

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Article

Conditional probability methods for haplotyping in pedigrees.

Genetics - 1 Aug 2004

Gao Guimin, Hoeschele Ina, Sorensen Peter, Du Fengxing

Abstract excerpt

Efficient haplotyping in pedigrees is important for the fine mapping of quantitative trait locus (QTL) or complex disease genes. To reconstruct haplotypes efficiently for a large pedigree with a large number of linked loci, two algorithms based on conditional probabilities and likelihood computations are presented. The first algorithm (the conditional probability method) produces a single, approximately optimal...

Topics

Animals
Female
Genetic Techniques
Genotype
Haplotypes
Humans
Male
Models, Genetic
Models, Statistical
Pedigree
Probability
Quantitative Trait Loci

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Open in PubMed Open full text

Identifiers

PMID: 15342540
DOI: 10.1534/genetics.103.021055
PMCID: PMC1470986

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