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Article

Positive selection on MMP3 regulation has shaped heart disease risk.

Current biology : CB - 7 Sept 2004

Rockman Matthew V, Hahn Matthew W, Soranzo Nicole, Loisel Dagan A, Goldstein David B, Wray Gregory A

Abstract excerpt

BACKGROUND: The evolutionary forces of mutation, natural selection, and genetic drift shape the pattern of phenotypic variation in nature, but the roles of these forces in defining the distributions of particular traits have been hard to disentangle. To better understand the mechanisms contributing to common variation in humans, we investigated the evolutionary history of a functional polymorphism in the upstream...

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Source

Identifiers

PMID: 15341739
DOI: 10.1016/j.cub.2004.08.051

Genes

MMP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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