Article
Mitochondrial disorders: clinical and genetic features.
Annual review of medicine - 1 Jan 1999
Simon D K, Johns D R
Abstract excerpt
Virtually all cells in humans depend on mitochondrial oxidative phosphorylation to generate energy, accounting for the remarkable diversity of clinical disorders associated with mitochondrial DNA mutations. However, certain tissues are particularly susceptible to mitochondrial dysfunction, resulting in recognizable clinical syndromes. Mitochondrial DNA mutations have been linked to seizures, strokes, optic...
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