Article
[A case of gastric GIST treated preoperatively by imatinib mesylate].
Gan to kagaku ryoho. Cancer & chemotherapy - 1 Aug 2004
Hiramatsu Yoshihiro, Konno Hiroyuki, Kamiya Kinji, Baba Megumi, Ohta Manabu, Kondo Kenji, Yamamoto Masayoshi, Kikuchi Hirotoshi, Tanaka Tatsuo, Sugimura Haruhiko, Nakamura Satoshi
Abstract excerpt
Gastrointestinal stromal tumor (GIST), the most common mesenchymal tumor of the human gastrointestinal tract, is thought to originate from the interstitial cells of Cajal. The mutation of c-kit, cording KIT, is essential in the development of GIST. Imatinib mesylate (IM), an agent for chronic myeloid leukemia, was reported to inhibit tyrosine kinase activity of KIT and to be highly effective for GIST. We report,...
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