[Clinical and molecular characterization of gastrointestinal stromal tumors (GIST)].

Abstract excerpt

Gastrointestinal stromal tumors (GIST) are rare mesenchymal tumors of the gastrointestinal tract, the diagnosis of which is difficult. The presence of membrane receptor c-KIT on GIST cells implies their origin from a precursor of interstitial cells of Cajal. Mutations in the c-kit gene result in the constitutive ligand-independent activation of the c-KIT receptor and, consequently, aberrant cell division and...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Benzamides
• Share to Enzyme Activation
• Share to Gastrointestinal Stromal Tumors