Article
[Gastrointestinal stromal tumor].
Gan to kagaku ryoho. Cancer & chemotherapy - 1 Mar 2004
Nishida Toshirou, Ohmori Takeshi, Matsuda Hikaru
Abstract excerpt
Gastrointestinal stromal tumors (GISTs), the most common submucosal tumor in the gut, express the KIT protein. Gain-of-function mutations in the KIT or PDGF-R alpha gene is involved in oncogenesis and growth of GISTs. Although the first-line therapy of resectable GISTs is surgery, imatinib mesyla...
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