Article
Diffuse growth pattern affects E-cadherin expression in invasive breast cancer.
Anticancer research - 1 Jan 2000
Brinck Ulrich, Jacobs Susanne, Neuss Michael, Tory Kalman, Rath Werner, Kulle Bettina, Füzesi Laszlo
Abstract excerpt
We investigated the correlations between growth patterns and E-cadherin expression by immunohistochemistry and the presence of mutations of exons 6-10 of the E-cadherin gene by PCR-SSCP, in 79 cases of invasive lobular and ductal breast cancer. E-cadherin expression showed a tendency to be lower in lobular than in ductal carcinomas (p=0.064). In 60% of lobular carcinomas the diffuse growth pattern and in 72% of...
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