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Saccharomyces cerevisiae RAD27 complements its Escherichia coli homolog in damage repair but not mutation avoidance.

Genes & genetic systems - 1 Jun 2004

Ohnishi Gaku, Daigaku Yasukazu, Nagata Yuki, Ihara Makoto, Yamamoto Kazuo

Abstract excerpt

In eukaryotes, the flap endonuclease of Rad27/Fen-1 is thought to play a critical role in lagging-strand DNA replication by removing ribonucleotides present at the 5' ends of Okazaki fragments, and in base excision repair by cleaving a 5' flap structure that may result during base excision repair. Saccharomyces cerevisiae rad27Delta mutants further display a repeat tract instability phenotype and a high rate of...

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Acetyltransferases
DNA Polymerase I
DNA Repair
Escherichia coli
Escherichia coli Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Flap Endonucleases

Genetic Complementation Test

Saccharomyces cerevisiae Proteins

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PMID: 15329499
DOI: 10.1266/ggs.79.183

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Saccharomyces cerevisiae RAD27 complements its Escherichia coli homolog in damage repair but not mutation avoidance.PMID 15329499Read ↗

Identification of rad27 mutations that confer differential defects in mutation avoidance, repeat tract instability, and flap cleavage.Semantic proximity Read ↗

Two distinct Okazaki fragment failure modes dominate mutagenesis in the absence of flap endonuclease 1.Semantic proximity Read ↗

The 3'-->5' exonuclease of DNA polymerase delta can substitute for the 5' flap endonuclease Rad27/Fen1 in processing Okazaki fragments and preventing genome instability.Semantic proximity Read ↗

Links between replication and recombination in Saccharomyces cerevisiae: a hypersensitive requirement for homologous recombination in the absence of Rad27 activity.Semantic proximity Read ↗

Functional analysis of human FEN1 in Saccharomyces cerevisiae and its role in genome stability.Semantic proximity Read ↗

Roles for the Rad27 Flap Endonuclease in Mitochondrial Mutagenesis and Double-Strand Break Repair in Saccharomyces cerevisiae.Semantic proximity Read ↗

A novel mutation avoidance mechanism dependent on S. cerevisiae RAD27 is distinct from DNA mismatch repair.Semantic proximity Read ↗

Suppression of Saccharomyces cerevisiae rad27 null mutant phenotypes by the 5' nuclease domain of Escherichia coli DNA polymerase I.Semantic proximity Read ↗

Novel function of Rad27 (FEN-1) in restricting short-sequence recombination.Semantic proximity Read ↗

Complementary functions of the Saccharomyces cerevisiae Rad2 family nucleases in Okazaki fragment maturation, mutation avoidance, and chromosome stability.Semantic proximity Read ↗

Saccharomyces cerevisiae flap endonuclease 1 uses flap equilibration to maintain triplet repeat stability.Semantic proximity Read ↗

Cleavage specificity of Saccharomyces cerevisiae flap endonuclease 1 suggests a double-flap structure as the cellular substrate.Semantic proximity Read ↗

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