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Article

Terbinafine Resistance Mediated by Salicylate 1-Monooxygenase inAspergillus nidulans

24 Aug 2004

Abstract excerpt

Resistance to antifungal agents is a recurring and growing problem among patients with systemic fungal infections. UV-induced Aspergillus nidulans mutants resistant to terbinafine have been identified, and we report here the characterization of one such gene. A sib-selected, 6.6-kb genomic DNA fragment encodes a salicylate 1-monooxygenase (salA), and a fatty acid synthase subunit (fasC) confers terbinafine...

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PMID: 15328121
DOI: 10.1128/aac.48.9.3530-3535.2004

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