Article
Identification of genes involved in terbinafine resistance in Aspergillus nidulans.
Letters in applied microbiology - 1 Jan 2002
Rocha E M F, Almeida C B, Martinez-Rossi N M
Abstract excerpt
AIMS: To determine the pattern and the genetic basis of resistance to terbinafine, a drug extensively used for the treatment of fungal infections in humans. METHODS AND RESULTS: Four resistant mutants from Aspergillus nidulans isolated after irradiation with ultraviolet light were crossed with the master strain F (MSF). Genetic analysis revealed that a single gene, located on chromosome IV, is responsible for...
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