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Article

Distribution of ITPA P32T alleles in multiple world populations.

Journal of human genetics - 1 Jan 2004

Marsh Sharon, King Cristi R, Ahluwalia Ranjeet, McLeod Howard L

Abstract excerpt

Dose-limiting toxicity from azathioprine treatment affects up to 37% of patients. Screening for thiopurine methyltransferase (TPMT) polymorphisms will prospectively identify approximately 10% of patients. Recently, a polymorphism in the inosine triphosphate pyrophosphatase gene (ITPA) has been associated with severe azathioprine toxicity. We demonstrate here that this proline to threonine substitution at codon 32...

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Source

Identifiers

PMID: 15322947
DOI: 10.1007/s10038-004-0183-y

Genes

ITPA
TPMT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Distribution of ITPA P32T alleles in multiple world populations.PMID 15322947Read ↗

Allele frequency of inosine triphosphate pyrophosphatase gene polymorphisms in a Japanese population.Semantic proximity Read ↗

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Polymorphism of the thiopurine S-methyltransferase gene in African-Americans.Semantic proximity Read ↗

Mutation in the ITPA gene predicts intolerance to azathioprine.Semantic proximity Read ↗

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