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Article

Functional study of the P32T ITPA variant associated with drug sensitivity in humans.

Journal of molecular biology - 25 Sept 2009

Stepchenkova Elena I, Tarakhovskaya Elena R, Spitler Kathryn, Frahm Christin, Menezes Miriam R, Simone Peter D, Kolar Carol, Marky Luis A, Borgstahl Gloria E O, Pavlov Youri I

Abstract excerpt

Sanitization of the cellular nucleotide pools from mutagenic base analogues is necessary for the accuracy of transcription and replication of genetic material and plays a substantial role in cancer prevention. The undesirable mutagenic, recombinogenic, and toxic incorporation of purine base analogues [i.e., ITP, dITP, XTP, dXTP, or 6-hydroxylaminopurine (HAP) deoxynucleoside triphosphate] into nucleic acids is...

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Source

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Identifiers

PMID: 19631656
DOI: 10.1016/j.jmb.2009.07.051
PMCID: PMC2745931

Genes

ITPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Functional study of the P32T ITPA variant associated with drug sensitivity in humans.PMID 19631656Read ↗

The human ITPA polymorphic variant P32T is destabilized by the unpacking of the hydrophobic core.Semantic proximity Read ↗

Quantitative in vitro and in vivo characterization of the human P32T mutant ITPase.Semantic proximity Read ↗

A disease spectrum for ITPA variation: advances in biochemical and clinical research.Semantic proximity Read ↗

Analysis of human ITPase nucleobase specificity by site-directed mutagenesis.Semantic proximity Read ↗

Inosine Triphosphate Pyrophosphatase (ITPase): Functions, Mutations, Polymorphisms and Its Impact on Cancer Therapies.Semantic proximity Read ↗

Characterization of a novel sequence variant, TPMT*28, in the human thiopurine methyltransferase gene.Semantic proximity Read ↗

Characterization of the inosine triphosphatase (ITPA) gene: haplotype structure, haplotype-phenotype correlation and promoter function.Semantic proximity Read ↗

Distribution of ITPA P32T alleles in multiple world populations.Semantic proximity Read ↗

The ITPA c.94C>A and g.IVS2+21A>C sequence variants contribute to missplicing of the ITPA gene.Semantic proximity Read ↗

Quantification and molecular characterization of hprt mutants of human T-lymphocytes.Semantic proximity Read ↗

Identification of a new missense mutation in exon 2 of the human hypoxanthine phosphoribosyltransferase gene (HPRTIsar): a further example of clinical heterogeneity in HPRT deficiencies.Semantic proximity Read ↗

Crystal structure of human inosine triphosphatase. Substrate binding and implication of the inosine triphosphatase deficiency mutation P32T.Semantic proximity Read ↗

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