Article
Genetic evidence identifying the true gluconeogenic fructose-1,6-bisphosphatase in Thermococcus kodakaraensis and other hyperthermophiles.
Journal of bacteriology - 1 Sept 2004
Sato Takaaki, Imanaka Hiroyuki, Rashid Naeem, Fukui Toshiaki, Atomi Haruyuki, Imanaka Tadayuki
Abstract excerpt
Fructose-1,6-bisphosphatase (FBPase) is one of the key enzymes in gluconeogenesis. Although FBPase activity has been detected in several hyperthermophiles, no orthologs corresponding to the classical FBPases from bacteria and eukaryotes have been identified in their genomes. An inositol monophosphatase (IMPase) from Methanococcus jannaschii which displayed both FBPase and IMPase activities and a structurally...
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