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Article

RANKing c-Jun in osteoclast development

16 Aug 2004

Abstract excerpt

Pathological bone loss always reflects enhanced net osteoclastic activity.Recognition and binding of the receptor activator of NF-κB (RANK) by RANK ligand (RANKL) is the key osteoclastogenic event, and the signaling cascades induced by this reaction therefore contain potential anti-osteoporosis therapeutic targets.A study reported in this issue of the JCI documents that a pivotal component of RANKL/RANK-mediated...

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PMID: 15314680
DOI: 10.1172/jci22644

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