Article
Differential kinetics of engraftment and induction of CD10 on human pre-B leukemia cell lines in immune deficient scid mice.
Leukemia - 1 Jan 1992
Kamel-Reid S, Dick J E, Greaves A, Murdoch B, Doedens M, Grunberger T, Thorner P, Freedman M H, Phillips R A, Letarte M
Abstract excerpt
The sensitivity of the scid mouse model was assessed by comparing the growth of two pre-B acute lymphoblastic leukemia (ALL) cell lines, A1 and G2, established from patients at relapse. When cell numbers varying from 10(4) to 10(7) were injected intravenously into scid mice, advanced growth and dissemination of leukemia was observed at 10-12 weeks with the G2 cells. Bone marrow, spleen and thymus contained high...
Topics
- Animals
- Antigens, Differentiation
- Antigens, Neoplasm
- Biomarkers, Tumor
- Child
- DNA, Neoplasm
- Flow Cytometry
- Humans
- Kinetics
- Mice
- Neoplasm Invasiveness