Article
Gene for the activating natural killer cell receptor, KIR2DS1, is associated with susceptibility to psoriasis vulgaris.
Human immunology - 1 Jul 2004
Łuszczek Wioleta, Mańczak Maria, Cisło Maria, Nockowski Piotr, Wiśniewski Andrzej, Jasek Monika, Kuśnierczyk Piotr
Abstract excerpt
Psoriasis vulgaris, particularly its juvenile form, is strongly associated with the HLA-Cw*06 allele encoding the HLA-Cw6 molecule. This molecule is recognized by the inhibitory receptor KIR2DL1 and the activatory receptor KIR2DS1, which are expressed on natural killer cells and subpopulations of T lymphocytes. Humans differ by the presence or absence of particular KIR genes. We hypothesized that either...
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