Article
Genetic polymorphisms of killer cell immunoglobulin-like receptors are associated with susceptibility to psoriasis vulgaris.
The Journal of investigative dermatology - 1 May 2004
Suzuki Yu, Hamamoto Yoshiaki, Ogasawara Yumie, Ishikawa Kimi, Yoshikawa Yoshiaki, Sasazuki Takehiko, Muto Masahiko
Abstract excerpt
To elucidate the association between killer cell immunoglobulin-like receptors (KIRs) and psoriasis vulgaris (PV), we typed 14 KIR genes in 96 Japanese cases and 50 healthy controls using PCR with sequence-specific primers (PCR-SSP). Here we report an interesting association between certain KIRs and Japanese cases with PV. The frequencies of KIR2DS1 and KIR2DL5 were significantly increased in PV cases compared...
Topics
- Genetic Predisposition to Disease
- Genotype
- Humans
- Japan
- Killer Cells, Natural
- Polymorphism, Genetic
- Psoriasis
- Receptors, Immunologic
- Receptors, KIR
- Receptors, KIR2DL1
- Receptors, KIR2DL2