Integration and independent acquisition of specialized skin- versus gut-homing and Th1 versus Th2 cytokine synthesis phenotypes in human CD4+ T cells.

Abstract excerpt

CD4+)T helper cells are heterogeneous in terms of tissue-specific homing and cytokine synthesis phenotypes. The mechanisms for the acquisition of tissue-specific homing phenotypes and their relationship with the attainment of polarized cytokine synthesis profiles of T cells are critically important but poorly understood. Here, we analyze the coordinate acquisition of Th1 versus Th2 cytokine (IFN-gamma vs. IL-4)...

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