Article
Tailoring the homing capacity of human Tregs for directed migration to sites of Th1-inflammation or intestinal regions.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 1 Jan 2019
Hoeppli R E, MacDonald K N, Leclair P, Fung V C W, Mojibian M, Gillies J, Rahavi S M R, Campbell A I M, Gandhi S K, Pesenacker A M, Reid G, Lim C J, Levings M K
Abstract excerpt
Cell-based therapy with CD4+ FOXP3+ regulatory T cells (Tregs) is a promising strategy to limit organ rejection and graft-vs-host disease. Ongoing clinical applications have yet to consider how human Tregs could be modified to direct their migration to specific inflammation sites and/or tissues for more targeted immunosuppression. We show here that stable, homing-receptor-tailored human Tregs can be generated...
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