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Article

Development of clinical paroxysmal nocturnal haemoglobinuria in children with aplastic anaemia.

British journal of haematology - 1 Sept 2017

Narita Atsushi, Muramatsu Hideki, Okuno Yusuke, Sekiya Yuko, Suzuki Kyogo, Hamada Motoharu, Kataoka Shinsuke, Ichikawa Daisuke, Taniguchi Rieko, Murakami Norihiro, Kojima Daiei, Nishikawa Eri, Kawashima Nozomu, Nishio Nobuhiro, Hama Asahito, Takahashi Yoshiyuki, Kojima Seiji

Abstract excerpt

The clinical significance of paroxysmal nocturnal haemoglobinuria (PNH) in children with aplastic anaemia (AA) remains unclear. We retrospectively studied 57 children with AA between 1992 and 2010. During the follow-up, five patients developed clinical PNH, in whom somatic PIGA mutations were detected by targeted sequencing. The 10-year probability of clinical PNH development was 10·2% (95% confidence interval,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28643364
DOI: 10.1111/bjh.14790

Genes

PIGA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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