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Article

Comparison of polymerase chain reaction-restriction fragment length polymorphism assay and enzyme assay for diagnosis of G(M1)-gangliosidosis in Shiba dogs.

Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc - 1 Jul 2004

Yamato Osamu, Kobayashi Asogi, Satoh Hiroyuki, Endoh Daiji, Shoda Toru, Masuoka Yukiko, Hatakeyama Ayano, Jo Eun-Og, Asano Tomoya, Yonemura Madoka, Yamasaki Masahiro, Maede Yoshimitsu

Abstract excerpt

In the present study, diagnostic methods for canine G(M1)-gangliosidosis were examined by comparing a DNA mutation assay with an enzyme assay. Sixty-two Shiba dogs of a pedigree with G(M1)-gangliosidosis were differentiated into 3 genotypes, i.e., normal, heterozygous, and homozygous affected dogs, using a DNA mutation assay, which consists of polymerase chain reaction amplification and the determination of...

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PMID: 15305740
DOI: 10.1177/104063870401600407

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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