Article
Isolation and characterization of the normal canine beta-galactosidase gene and its mutation in a dog model of GM1-gangliosidosis.
Journal of inherited metabolic disease - 1 Sept 2000
Wang Z H, Zeng B, Shibuya H, Johnson G S, Alroy J, Pastores G M, Raghavan S, Kolodny E H
Abstract excerpt
The acid beta-galactosidase cDNA of Portuguese Water dogs was isolated and sequenced. The entire coding region of the gene consists of 2004 nucleotides encoding a protein of 668 amino acids. Its encoding sequence indicates approximately 86.5% identity at the nucleotide level and about 81% identity at the amino acid level with the encoding region of the human acid beta-galactosidase gene. The deduced amino acid...
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