Article
Importance of a developmentally regulated pheromone receptor of Cryptococcus neoformans for virulence.
Infection and immunity - 1 Sept 2003
Chang Yun C, Miller Georgina F, Kwon-Chung K J
Abstract excerpt
Cryptococcus neoformans is the etiologic agent of cryptococcosis. Two mating types exist in this fungus, MAT alpha and MATa. The CPRa gene of C. neoformans is a MATa strain-specific gene and encodes a putative seven-transmembrane domain pheromone receptor. Unlike the other reported fungal pheromone receptors, CPRa shows functional diversity. Deletion of CPRa drastically affects mating efficiency but does not...
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