Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A disorder to order transition accompanies catalysis in retinaldehyde dehydrogenase type II.

The Journal of biological chemistry - 8 Oct 2004

Bordelon Tee, Montegudo Sarah K, Pakhomova Svetlana, Oldham Michael L, Newcomer Marcia E

Abstract excerpt

Retinaldehyde dehydrogenase II (RalDH2) converts retinal to the transcriptional regulator retinoic acid in the developing embryo. The x-ray structure of the enzyme revealed an important structural difference between this protein and other aldehyde dehydrogenases of the same enzyme superfamily; a 20-amino acid span in the substrate access channel in retinaldehyde dehydrogenase II is disordered, whereas in other...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aldehyde Oxidoreductases
Share to Histidine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Retinal Dehydrogenase

Share to Spectrometry, Fluorescence

Share to Spectrophotometry

Share to Tretinoin

Share to X-Rays

Source

Identifiers

PMID: 15299009
DOI: 10.1074/jbc.M406139200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A disorder to order transition accompanies catalysis in retinaldehyde dehydrogenase type II.PMID 15299009Read ↗

Chemical perturbation of an intrinsically disordered region of TFIID distinguishes two modes of transcription initiationSemantic proximity Read ↗

Insights into Aldehyde Dehydrogenase Enzymes: A Structural PerspectiveSemantic proximity Read ↗

A helical lid converts a sulfotransferase to a dehydratase.Semantic proximity Read ↗

Structural basis for the high <i>all-trans</i> -retinaldehyde reductase activity of the tumor marker AKR1B10Semantic proximity Read ↗

Interrogating the Inhibition Mechanisms of Human Aldehyde Oxidase by X-ray Crystallography and NMR Spectroscopy: The Raloxifene Case.Semantic proximity Read ↗

Reassignment of the human aldehyde dehydrogenase ALDH8A1 (ALDH12) to the kynurenine pathway in tryptophan catabolism.Semantic proximity Read ↗

Focus on molecules: retinol dehydrogenase 12 (RDH12).Semantic proximity Read ↗

A gatekeeper helix determines the substrate specificity of Sjögren-Larsson Syndrome enzyme fatty aldehyde dehydrogenase.Semantic proximity Read ↗

Structural Insights into the Drosophila melanogaster Retinol Dehydrogenase, a Member of the Short-Chain Dehydrogenase/Reductase Family.Semantic proximity Read ↗

Protein design: reengineering cellular retinoic acid binding protein II into a rhodopsin protein mimic.Semantic proximity Read ↗

Transporter-to-trap conversion: a disulfide bond formation in cellular retinoic acid binding protein I mutant triggered by retinoic acid binding irreversibly locks the ligand inside the protein.Semantic proximity Read ↗

Understanding heme transport.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.