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Article

Protein design: reengineering cellular retinoic acid binding protein II into a rhodopsin protein mimic.

Journal of the American Chemical Society - 16 May 2007

Vasileiou Chrysoula, Vaezeslami Soheila, Crist Rachael M, Rabago-Smith Montserrat, Geiger James H, Borhan Babak

Abstract excerpt

Rational redesign of the binding pocket of Cellular Retinoic Acid Binding Protein II (CRABPII) has provided a mutant that can bind retinal as a protonated Schiff base, mimicking the binding observed in rhodopsin. The reengineering was accomplished through a series of choreographed manipulations to ultimately orient the reactive species (the epsilon-amino group of Lys132 and the carbonyl of retinal) in the proper...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17447762
DOI: 10.1021/ja067546r

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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