Article
The Clara cell10 adenine38guanine polymorphism and sarcoidosis susceptibility in Dutch and Japanese subjects.
American journal of respiratory and critical care medicine - 1 Dec 2004
Janssen Rob, Sato Hiroe, Grutters Jan C, Ruven Henk J T, du Bois Ron M, Matsuura Ryosuke, Yamazaki Masao, Kunimaru Shigeki, Izumi Takateru, Welsh Ken I, Nagai Sonoko, van den Bosch Jules M M
Abstract excerpt
CC10 (CC16, uteroglobin) is a pulmonary protein postulated to play a counter regulatory role in sarcoidosis pathogenesis. The adenine38guanine (A38G) polymorphism of the encoding CC10 gene (SCGB1A1) is functional. Recently, an association between the low CC10 producing 38A allele and sarcoidosis susceptibility has been reported in Japanese patients from Hokkaido. The aim of the present study was to confirm this...
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