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Article

The AZFa gene DBY (DDX3Y) is widely transcribed but the protein is limited to the male germ cells by translation control

4 Aug 2004

Abstract excerpt

We explored the function of the human DEAD-box Y RNA helicase DBY (DDX3Y) gene located in the (AZFa) region on the human Y chromosome (Yq11.21). Deletion of this Y interval is known to be a major cause for the occurrence of a severe testicular pathology, the Sertoli-cell-only (SCO) syndrome. DBY has a structural homologue on the short arm of the X chromosome DBX (DDX3X) (Xp11.4). We found widespread transcription...

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Identifiers

PMID: 15294876
DOI: 10.1093/hmg/ddh240

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The AZFa gene DBY (DDX3Y) is widely transcribed but the protein is limited to the male germ cells by translation controlPMID 15294876Read ↗

DDX3X, the X homologue of AZFa gene DDX3Y, expresses a complex pattern of transcript variants only in the male germ line.Semantic proximity Read ↗

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AZFa protein DDX3Y is differentially expressed in human male germ cells during development and in testicular tumours: new evidence for phenotypic plasticity of germ cells.Semantic proximity Read ↗

AZFa Y Gene, DDX3Y, Evolved Novel Testis Transcript Variants in Primates with Proximal 3´UTR Polyadenylation for Germ Cell Specific TranslationSemantic proximity Read ↗

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