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Article

The murine gastrin promoter is synergistically activated by transforming growth factor-beta/Smad and Wnt signaling pathways.

The Journal of biological chemistry - 8 Oct 2004

Lei Shi, Dubeykovskiy Alexander, Chakladar Abhijit, Wojtukiewicz Lindsay, Wang Timothy C

Abstract excerpt

The transforming growth factor-beta (TGF-beta) and Wnt/wingless pathways play critical roles in the specification of cell fate during development and also contribute to cancer formation and progression. Whereas Wnt signaling is clearly pro-oncogenic, TGF-beta signaling is cell- and context-dependent, manifesting both inhibitory and proliferative effects. The growth factor, gastrin, has previously been shown to be...

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Source

Identifiers

PMID: 15292219
DOI: 10.1074/jbc.M404025200

Genes

TCF4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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