Article
Deletion and aberrant CpG island methylation of Caspase 8 gene in medulloblastoma.
Oncology reports - 1 Sept 2004
Gonzalez-Gomez Pilar, Bello M Josefa, Inda M Mar, Alonso M Eva, Arjona Dolores, Amiñoso Cinthia, Lopez-Marin Isabel, de Campos Jose M, Sarasa Jose L, Castresana Javier S, Rey Juan A
Abstract excerpt
Aberrant methylation of promoter CpG islands in human genes is an alternative genetic inactivation mechanism that contributes to the development of human tumors. Nevertheless, few studies have analyzed methylation in medulloblastomas. We determined the frequency of aberrant CpG island methylation for Caspase 8 (CASP8) in a group of 24 medulloblastomas arising in 8 adult and 16 pediatric patients. Complete...
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