Article
Crystal structure and mutagenesis of a protein phosphatase-1:calcineurin hybrid elucidate the role of the beta12-beta13 loop in inhibitor binding.
The Journal of biological chemistry - 8 Oct 2004
Maynes Jason T, Perreault Kathleen R, Cherney Maia M, Luu Hue Anh, James Michael N G, Holmes Charles F B
Abstract excerpt
Protein phosphatase-1 and protein phosphatase-2B (calcineurin) are eukaryotic serine/threonine phosphatases that share 40% sequence identity in their catalytic subunits. Despite the similarities in sequence, these phosphatases are widely divergent when it comes to inhibition by natural product toxins, such as microcystin-LR and okadaic acid. The most prominent region of non-conserved sequence between these...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.