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Article

Site-directed mutagenesis of amino acid residues of protein phosphatase 1 involved in catalysis and inhibitor binding.

Proceedings of the National Academy of Sciences of the United States of America - 15 Apr 1997

Huang H B, Horiuchi A, Goldberg J, Greengard P, Nairn A C

Abstract excerpt

Site-directed mutagenesis of selected residues of mammalian protein phosphatase 1 (PP-1) has been carried out to further define the mechanism of catalysis, activation by divalent cations, and inhibition by toxins and inhibitory proteins. Mutation of active site residues predicted to bind metals (...

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Identifiers

PMID: 9108010
DOI: 10.1073/pnas.94.8.3530
PMCID: PMC20473

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-9108010-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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