Article
Relationships between cagA, vacA, and iceA genotypes of Helicobacter pylori and DNA damage in the gastric mucosa.
Environmental and molecular mutagenesis - 1 Jan 2004
Ladeira Marcelo S P, Rodrigues Maria A M, Salvadori Daisy M F, Neto Pedro Padulla, Achilles Pedro, Lerco Mauro M, Rodrigues Paulo A, Gonçalves Irio, Queiroz Dulciene M M, Freire-Maia Dértia V
Abstract excerpt
Helicobacter pylori (H. pylori) is believed to predispose carriers to gastric cancer by inducing chronic inflammation. The inflammatory processes may result in the generation of reactive oxygen and nitrogen species that damage DNA. In this study, we investigated the relationships between DNA damage in the gastric mucosa and cagA, vacA, and iceA genotypes of H. pylori. The study was conducted with biopsies from...
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