Article
On the mechanism of action of the antifungal agent propionate.
European journal of biochemistry - 1 Aug 2004
Brock Matthias, Buckel Wolfgang
Abstract excerpt
Propionate is used to protect bread and animal feed from moulds. The mode of action of this short-chain fatty acid was studied using Aspergillus nidulans as a model organism. The filamentous fungus is able to grow slowly on propionate, which is oxidized to acetyl-CoA via propionyl-CoA, methylcitrate and pyruvate. Propionate inhibits growth of A. nidulans on glucose but not on acetate; the latter was shown to...
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