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Article

Control of filament formation in Candida albicans by polyamine levels.

Infection and immunity - 1 Sept 1999

Herrero A B, López M C, García S, Schmidt A, Spaltmann F, Ruiz-Herrera J, Dominguez A

Abstract excerpt

Candida albicans, the most common fungal pathogen, regulates its cellular morphology in response to environmental conditions. The ODC gene, which encodes ornithine decarboxylase, a key enzyme in polyamine biosynthesis, was isolated and disrupted. Homozygous null Candida mutants behaved as polyamine auxotrophs and grew exclusively in the yeast form at low polyamine levels (0.01 mM putrescine) under all conditions...

Topics

Alleles
Animals
Candida albicans
Chromosome Deletion
Chromosomes, Fungal
Male
Mice
Ornithine Decarboxylase
Phenotype
Polyamines

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 10456943
DOI: 10.1128/IAI.67.9.4870-4878.1999
PMCID: PMC96821

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