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Article

Methylcitrate synthase from Aspergillus fumigatus. Propionyl-CoA affects polyketide synthesis, growth and morphology of conidia.

The FEBS journal - 1 Jul 2005

Maerker Claudia, Rohde Manfred, Brakhage Axel A, Brock Matthias

Abstract excerpt

Methylcitrate synthase is a key enzyme of the methylcitrate cycle and required for fungal propionate degradation. Propionate not only serves as a carbon source, but also acts as a food preservative (E280-283) and possesses a negative effect on polyketide synthesis. To investigate propionate metabolism from the opportunistic human pathogenic fungus Aspergillus fumigatus, methylcitrate synthase was purified to...

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PMID: 16008561
DOI: 10.1111/j.1742-4658.2005.04784.x

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