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Article

Fungal metabolic model for 3-methylcrotonyl-CoA carboxylase deficiency.

The Journal of biological chemistry - 6 Feb 2004

Rodríguez José M, Ruíz-Sala Pedro, Ugarte Magdalena, Peñalva Miguel A

Abstract excerpt

Aspergillus nidulans is able to use Leu as the sole carbon source through a metabolic pathway leading to acetyl-CoA and acetoacetate that is homologous to that used by humans. mccA and mccB, the genes encoding the subunits of 3-methylcrotonyl-CoA carboxylase, are clustered with ivdA encoding isovaleryl-CoA dehydrogenase, a third gene of the Leu catabolic pathway, on the left arm of chromosome III. Their...

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PMID: 14612443
DOI: 10.1074/jbc.M310055200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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